You will find there's release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to lessen afferent pain transmission and deliver analgesia. Hence, drugs like clonidine that focus on alpha-two receptors can affect the transmission of soreness. Applies to clonidine: oral pill, https://conolidine75296.bloginder.com/36461150/the-smart-trick-of-onolidine-that-no-one-is-discussing