During the LSD-sure crystal structure, the side chain of your lid residue L209EL2 types intensive hydrophobic contacts with the two LSD and bordering residues in TMs III, IV, and V (Figure 4C). Once the lid moved apart to expose the binding pocket in simulation, various of such contacts broke. We https://moodjhomedia.com/story2869044/lsd-crystal-for-dummies