There is a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to reduce afferent pain transmission and develop analgesia. For that reason, prescription drugs like clonidine that focus on alpha-two receptors can impact the transmission of soreness. Jun ten, https://toplistar.com/story21782065/onolidine-an-overview