Background: Alveolar bone defects in children still have a high incidence. Conventional bone graft technique that has been used as a defect therapy is still not effective. so new techniques with tissue engineering approach are needed. Bone Morphogenetic Protein 4 (BMP4) as one of the indicators of osteogenic differentiation has not been widely studied. https://www.diegojavierfares.com/amazing-price-Kicker-48CDF104-Comp-10-Down-Firing-Loaded-Subwoofer-Enclosure-special-find/