This refers to how an allosteric modulator impacts signaling for a particular orthosteric agonist. By way of example, an allosteric modulator may change THC signaling, although not endogenous cannabinoid signaling. A very important probable endogenous detrimental allosteric modulator for CB1 is definitely the steroid hormone, pregnenolone [forty–forty two]. Some (though https://jaidenhqwdk.blogunteer.com/31862266/tetrahydrocannabinol-thc-an-overview