It takes a couple of days to get a cortisone shot to kick in because the cells in the lining with the joint interact with the injectable steroid. This delay is why a cortisone shot is normally coupled with an anesthetic, like lidocaine or bupivacaine, for more rapidly pain reduction. https://injectable-steroids60370.boyblogguide.com/30909772/the-5-second-trick-for-injectable-steroids