Gastrointestinal (GI): NSAIDs that block COX-one activity have correlations with GI complications due to inhibition of your synthesis of gastroprotective agents for instance PGE2 and also other prostaglandins. This inhibition causes lowered mucin generation by gastric epithelial cells, significantly less bicarbonate secretion, and less epithelial cell turnover, amid other actions. https://erico219yvs1.blogoxo.com/profile