Chemotherapy was potentiated by E7449 and one agent experienced major antitumor activity in BRCA-deficient xenografts. Additionally, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell traces, very likely by TNKS inhibition. In step with this risk, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and noticeably altered expression of Wnt https://asenacaz974qwz8.bloggactivo.com/profile