At the moment, there are two styles of research on itaconate: Irg1−/− macrophages and the regulatory outcome of itaconate derivatives. Both of these results ended up complementary and uncovered that the regulatory mechanisms of itaconate involved alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription issue 3 (ATF3) https://le30022009.digiblogbox.com/55044404/facts-about-4-octyl-itaconate-revealed